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Acknowledgments The work in this study was supported by the Natural Science Foundation of China (grants 30971188, 81273279, 81302560, and 81373201)

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It is a short chain of three amino acids (alanine, histidine, and lysine) bound to a copper ion

Animal models are valuable tools for identifying mechanisms and establishing safety signals, but they are not designed to prove clinical efficacy in humans

it has been shown to normalize NO levels in conditions of both over- and under-production, suggesting a homeostatic regulatory role