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Washington, DC: American Psychiatric Association

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[3] Along with urine discoloration, some individuals notice a change in the color of the stool or a bluish tinge to the skin, especially at higher doses or with IV use

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Strategies that reduce local and systemic oxidative stress, stabilize upper dermis mast cells, decrease melanogenesis without melanocyte toxicity, remove epidermal melanin without inflammatory stimulus, revert senescence, and induce autophagy are considered promising

The authors suggested that the higher incidence of inclusions in liver might be related to slowing of the tumor growth leading to lower incidence of hepatocellular tumors in C57BL/6 mice