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These range from FDA-approved medications, such as GLP-1 receptor agonists (Wegovy, Zepbound) for weight loss, to unregulated compounds with minimal or no human safety data

It is important to note that cross-trial comparisons have significant limitations

In humans, GLP-1 alters palatable food intake and improves activity deficits in the insula, hypothalamus, and orbito-frontal cortex (OFC)

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And since enhancing satiety is one of the major challenges in the dietary treatment of obesity and type 2 diabetes, plant-based meals may be an effective strategy in solving this problem