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The Wegovy prescribing information specifically cautions that adverse-reaction rates from one drug's clinical trials cannot be directly compared with another drug's trial rates

Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E / insulin receptor substrate 2 +/ (APOE / irs2 +/ ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)

doi: 10.1001/jama.2023.19897 25

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