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Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion

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Medicare, the federal health program for adults 65 and older, has been prohibited by law from covering weight loss drugs for older Americans who are obese but do not have diabetes or heart disease

The SURPASS phase III clinical trials for tirzepatide involve more than 13,000 patients with T2D and aim to gain a better understanding of its efficacy and safety (ClinicalTrials.gov Identifier: NCT04255433)