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Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS: Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects
Several landmark trials explain why GLP-1 medications became famous
Use of the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH for the manufacture of a medicament for use in the treatment by multiple agent therapy with a PDE-5 inhibitor for the treatment sexual dysfunction, wherein the amount of each of the peptide Ac-Nle- cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH and the PDE-5 inhibitor is not sufficient, if administered as monotherapy, to independently initiate the desired pharmacological response in the patient
Specifically, the concentration and timing of drug administration significantly impact therapeutic responses
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