Graphical abstract Fig
Stable isotope dilution LC-MS/MS was used to quantify d 9 -TMAO ( A ), d 9 -BB ( B ), and d 9 -l-carnitine ( C ) in plasma collected from sequential venous blood draws at the noted times
Each step up delivers approximately 3 additional percentage points of total body weight reduction
We observed an initial blunted response at time points 10 ( BrAC Control = 0.037, BrAC GLP-1RA = 0.021, t(113) = 3.21, p = 0.014), 15 ( BrAC Control = 0.028, BrAC GLP-1RA = 0.013, t(113) = 2.98, p = 0.028) and 20 min (BrAC Control = 0.037, BrAC GLP-1RA = 0.017, t(113) = 3.87, p = 0.001) in the GLP-1RA group as compared to the control group
3 mg/kg) or vehicle respectively (combined with acute PVN injections of Bicuculline Methiodide 3 min prior to CNO administration when stated)
Bernier, L.-P