Semaglutide: Selective GLP-1 receptor agonist
Your body has re-sensitized, which means the same dose that barely affected you before the break may now produce significant effects, including potentially severe gastrointestinal side effects
Additionally, GLP-1 can inhibit apoptosis by activating the PI3K/Akt pathway, promoting the anti-apoptotic protein Bcl-2 and hindering the activity of caspases
These are not milligram-for-milligram equivalents, and starting tirzepatide at too high a dose because you were on a high semaglutide dose can produce severe side effects
Check out our comparison of Retatrutide vs Tirzepatide to see how these treatments differ
Safety Considerations and Clinical Eligibility GLP-1 medications, as described in SkinnyRx's published patient protocols, are intended for adults aged 18 and older