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As habituation to the stimulus persisted even after calcium levels returned to their baseline levels (Fig 4A), a second, calciumindependent inhibitory process may also exist

NATIVE study will investigate the safety and efficacy of two doses of IVA337 (800 and 1200 mg/day) over a 24-week period and will enroll up to 225 patients in 12 European countries (NCT03008070)

The electrical impulses that initiate a heartbeat may be too fast, too slow, or inconsistent