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This is particularly important with tirzepatide, which can reduce oral contraceptive exposure during initiation and dose escalation, potentially requiring backup contraception

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Mitochondrial GSH transport (via SLC25A39) and the Nrf2-ARE regulatory pathway constitute key regulatory mechanisms at the tissue/cellular level, ensuring that GSH metabolism adapts to different physiological and pathological states

The format is flexible, but the protein anchor is non-negotiable