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Pardo M, Cheng Y, Velmeshev D, Magistri M, Eldar-Finkelman H, Martinez A, Faghihi MA, Jope RS, Beurel E (2017) Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

The answer depends on your treatment duration, dose level, and individual metabolic response, but evidence suggests a structured approach minimizes rebound weight gain