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This metabolic perturbation, coupled with lactate-mediated feedback inhibition of phosphofructokinase-1, ultimately impairs cellular ATP homeostasis and compromises GSH biosynthesis, the predominant intracellular antioxidant (50)

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There are also oversight concerns

NAION causes devastating vision loss that occurs suddenly and usually affects one eye, though the second eye develops NAION in approximately 15-25% of cases within five years

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