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When older individuals have been studied, analyses from trials such as Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) suggested that more frail individuals have worse outcomes and benefit less from intensive control of blood glucose levels and blood pressure [263]

Exposure to the study drugs was additionally assessed continuously during follow-up (~per-protocol trial analysis), with censoring at the time of discontinuation or shift to the comparator drug