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The Pyo 2007 study (PMID 17703734) reported that AHK-Cu raised VEGF production in the treated cells

Ethics statement The animal study was reviewed and approved by the Research Ethics Committee of Xian Jiaotong University

These findings support the hypothesis that gastrointestinal dysfunction could precede motor symptoms in PD

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Collectively, these interlinked mechanisms demonstrate that the Nrf2-Keap1 and NLRP3 pathways form a dynamic regulatory axis in PD, in which redox balance mitochondrial integrity and inflammatory signaling are tightly coupled

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