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Ya BL, Liu Q, Li HF et al

& Hochstein, S

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Some GLP-1 medication users report muscle pain and body aches as side effects

Discovered in 2015 by Changhan David Lee and Pinchas Cohen at USC, MOTS-c is encoded in the 12S rRNA region of the mitochondrial genomemaking it one of a small but growing family of mitochondrial-derived peptides (MDPs) that challenge the longstanding view of mitochondria as passive energy factories

Furthermore, bacterial metabolites such as SCFA increase the rate-limiting enzymes in the synthesis of noradrenaline, dopamine, and serotonin [76]