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Abbreviations BBB: Blood-brain barrier CGRP: Calcitonin gene-related peptide CM: Chronic migraine CNS: Central nervous system CSD: Cortical spreading depression DMEM: Dulbeccos modified Eagles medium FBS: Foetal bovine serum GLP-1R: Glucagon-like peptide-1 receptor IGF-1: Insulin-like growth factor-1 IS: Inflammatory soup LPS: Lipopolysaccharide NTG: Nitroglycerin PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PMSF: Phenylmethylsulfonyl fluoride RT: Room temperature TNC: Trigeminal nucleus caudalis References May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment

High-sulfur foods to limit or avoid The primary dietary triggers for sulfur burps are foods rich in sulfur-containing amino acids (cysteine and methionine) and sulfur compounds

High concentrations should be diluted using Normal Saline Injection when given intravenously

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Semaglutide was extensively tested in several phase 3 trials for its therapeutic potential, including as part of the Semaglutide Treatment Effect in People with Obesity (STEP) and Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical programs

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