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In contrast, stimulation of apical TLR9 by luminal contents induces a net inhibitory effect, reinforcing the unique ability of IECs to distinguish between signals despite using the same receptors at different spatiotemporal positions (Lee et al

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After the model was expanded to include GS-H 2 Q adduct formation as a function of its reduction potential, it was then combined with the Reed glutathione model 21 in order to simulate how the quinone redox-metabolism of doxorubicin influenced the glutathione metabolism

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Thus, findings from ARPE-19 cells may provide indirect mechanistic insights for future research into T