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During lyophilization, water molecules are removed under vacuum, leaving a stable powder that can withstand storage and shipping without refrigeration
Key Takeaways Tirzepatide and semaglutide are both once-weekly injectable medications for diabetes and weight management, but tirzepatide targets both GLP-1 and GIP receptors while semaglutide targets only GLP-1
Knudsen, L
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Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues
Protect from light UV exposure degrades peptides
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