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Of note, mitochondrial permeability transition pore (mPTP) has been implicated in oxidative stress-induced necrosis as well as ischemia/reperfusion injury 7

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We find that at 310 K, a single permeation event occurs on a timescale of 10 1 ns, while at 440 K the timescale is 10 1 to 10 0 ns

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Patients injecting 3+ times weekly can use pre-mixed vials without significant waste since they'll exhaust the vial before oxidation becomes critical