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These data demonstrate that metformin alters metabolism, specifically inhibiting oxidative phosphorylation, and induces significant mitochondrial dysfunction in both HCT116 and SW837 cells, supporting its metabolic modulatory effects in CRC in vitro

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[] Because of its anti-inflammatory qualities and ability to raise extracellular glutamate levels, NAC may have depressive properties

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In addition, over 99% of the total glutathione produced under these conditions was in the biologically active, reduced form (GSH)