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Combine both at reduced individual doses to leverage the complementary benefits of each while potentially minimizing the drawbacks of using either at full dose

Knockouts of the ThDP transporter SLC44A4 in mice display an upregulation of genes associated with colonic inflammation, and increased susceptibility to dextran sodium sulfate-induced colitis, accompanied by significant weight loss and shortening of the colon (204)

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In OA FLS, integrin v6 plays a critical role due to its upregulated expression upon TGF-1 stimulation and in mediating the activation of TGF-