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[31] Since L-carnitine has a central role in fat metabolism and has significant antioxidant properties as well, carnitine supplementation has been investigated as a treatment option in the management of type 2 diabetes

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The primary effectors of cAMP, protein kinase A (PKA), and the cAMP-regulated guanine nucleotide exchange factor (Epac) play crucial roles in this process [22]

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Excess androgens driven by insulin resistance blunt the progesterone and oestrogen feedback that normally regulates kisspeptin neuronal activity