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The use of H(2)-receptor antagonists and/or PPIs may impair the absorption of protein-bound dietary vitamin B12 and could contribute to the development of vitamin B12 deficiency with prolonged use.[189] The studies reviewed in this article clearly show that omeprazole therapy will decrease the absorption of vitamin B12 by preventing its cleavage from dietary proteins.[190] A number of studies have shown an association of decreased B12 absorption with prolonged PPI use.[189,190] However, PPIs have been shown to affect B12 absorption in very short periods of time as well.[191,192] One study showed a 72% decrease in B12 absorption on 20 mg of omeprazole (Prilosec) and an 88% decrease in B12 absorption on 40 mg of omeprazole after only 2 weeks of treatment

Is a higher dose always better

Mountainside Medical recommends that all clinical use decisions be made in accordance with the relevant drug prescribing information, institutional protocols, and applicable USP standards

Though outcomes will differ, numerous patients questioning what do b12 shots do are amazed at how much more alert and awake they become when getting routine injections

Our body and state of health are all so different, I dont think there is really any way to know beforehand how you will feel from trying this out