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Kidney function tests (serum creatinine, urinalysis, spot urine protein/creatinine ratio)

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The 12-week escalation period is necessary for safety and tolerability

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39 An additional therapy that has been studied for use in HFpEF is the interatrial shunting device (IASD), which aims to relieve left atrial pressure through the artificial creation of connection between atria (or in some approaches between the left atrium and coronary sinus)

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