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Besides this, the combined therapy of l-carnitine and metformin further significantly decreased the time spent at the periphery of the open field as compared to the untreated diabetic rats and metformin-alone-treated diabetic rats

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A recent case report suggests that such medications can influence brain regions involved in emotional regulation and potentially trigger or worsen severe depressive symptoms

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J Neurochem 43:13691374 Bradl M, Hohlfeld R (2003) Molecular pathogenesis of neuroinflammation

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