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Herrera-Ruiz reported that PepT1 appears to be localized predominantly in the duodenum, with decreasing expression in the jejunum and ileum (Herrera-Ruiz et al

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52 Oral ingestion of forskolin stimulates chloride and water secretion into the intestinal lumen, reduces water reabsorption, and causes decreased smooth muscle relaxation and cAMP modulation in the intestines, contributing to diarrhea

Interferon with or without ribavirin is the only drug with proven efficacy in treating chronic HCV infections [20]