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Senescent VSMCs exhibit upregulation of RUNX2, while knockdown of RUNX2 resulted in a significant reduction of osteoblast markers, as well as in calcification (77)

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This therapy is not recommended for individuals who are pregnant, breastfeeding, or have certain medical conditions

Dull or Uneven Skin Tone

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

Ginsenoside Rg1, ginsenoside Re, notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rd are the main saponins that cause these effects [286]