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The onset of T2DM is closely related to the presence of obesity in PWS, the latter related to an insufficient and delayed satiety response, due to uncontrolled food intake mechanisms caused by a hypothalamic dysfunction (192)

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A separate meta-analysis provides evidence to this theory as higher recipient age and pre-LT T2DM were both independent risk factors for post-LT mortality in MASH patients [114]

[1] Adhikari, R., Jha, K., Dardari, Z., Heyward, J., Blumenthal, R.S., Eckel, R.H., Alexander, G.C., Blaha, M.J., (2022)

These vitamins work synergistically, enhancing each others antioxidative properties while boosting collagen production