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The kidney specific outcome was a composite of ESKD, doubling of creatinine or death from a renal cause, and was reduced by 34% in the treatment group (HR, 0.66

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Rivlin N, Brosh R, Oren M, Rotter V

It has been theorized that the chemicals in coffee enemas cause free radicals to be absorbed by the sulfhydryl (-SH) groups of glutathione in the bile, which thereafter become bile salts that are flushed out of the gall bladder [20]

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