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Patients should contact their healthcare provider if they experience severe or persistent heartburn that does not respond to conservative measures or over-the-counter treatments within 1-2 weeks, as this may indicate more significant gastroesophageal pathology requiring investigation

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3 College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, 22384, Saudi Arabia

However, the reconstituted peptides own chemical stability is the determining factor for effective use window