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doi: 10.1016/j.biochi.2011.08.011

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The Underdose Risk: Consistently under-dosing prevents the drug from reaching the steady-state concentration needed for weight loss, resulting in a therapeutic stall. Pharmacokinetics: The Steady State Myth The logical basis for split dosing is often the desire to avoid the trough period: the final 48 hours before the next shot when hunger returns