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Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

Malabsorption can cause severe B12 deficiency

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Another such example is Metformin , which is a medication for type 2 diabetes, which can also interfere with B12 absorption in the gut