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Semaglutide itself is not known to cause menstrual irregularities when used with oral contraceptives

Many people also notice modest weight loss as a secondary benefit, which is why clinicians sometimes choose it when both glucose control and weight are concerns

In addition, orlistat's potential to cause liver damage and its association with severe liver outcomes, such as gallstone formation, obstructive jaundice, and acute liver failure, have been documented [68, 70]

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