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It typically occurs secondarily due to dehydration from gastrointestinal side effects such as nausea, vomiting, and diarrhoea, which are common, particularly during treatment initiation and dose escalation

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doi: 10.1016/j.immuni.2015.06.010

All experimental procedures were in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research, and the guidelines of the Institutional Animal Care and Use Committee

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