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probiotics and plant-derived products), but high-quality evidence is scarce ( A more personalized approach in the management of patients with IBS is desirable, and for now, targeting the most bothersome predominant symptoms in IBS-D (i.e., loose stools, abdominal pain, and/or bloating) seems to be the only practical and suitable treatment strategy

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In older or frail populations, concerns include lean-mass loss, aspiration risk during procedures, sarcopenia, falls, and worsening dysphagia

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