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The tradeoff is that you're getting astaxanthin alone

Natural antioxidant activities of plants in preventing cataractogenesis

It plays a central role in protecting cells from oxidative damage by neutralising free radicals, and is essential for mitochondrial function and cellular redox balance

Anisimov, V

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Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6