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Here, hypoxia-inducible factor 1-alpha (HIF-1) emerges as a central regulator, dismantling cuproptosis through a dual strategy: by upregulating copper-chelating metallothioneins and by metabolically reprogramming cells to downregulate DLAT, a key enzyme in the lipoylation pathway essential for cuproptosis execution [52, 61]

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In most cases, diarrhoea can be managed effectively with dietary changes and supportive treatments

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