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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)
Zhu Ls team explored the potential of hUC-MSC transplantation in repairing vaginal tissue damage in a de-ovulated rhesus monkey model
Here, we unveil the detrimental effect of a high cholesterol diet on GLP-1R-dependent glucoregulation in vivo , and the improvement in GLP-1R function that a reduction in cholesterol synthesis using simvastatin exerts in pancreatic islets
MicroRNAs are a category of non-coding RNAs featuring a 22-base sequence, which exert regulatory effects on gene expression via post-transcriptional modification of target mRNAs (Makeyev and Maniatis, 2008), studies have indicated that microRNAs participate in numerous key biological processes, including cell proliferation and apoptosis (Huber et al., 2015
