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One study showed that topical treatment twice a day for 3 months with 5% glycolic acid at pH 2.8 affected surface and epidermal changes, while the same treatment, but with a 12% reached deeper and influenced both the epidermis and the deeper dermis layer, and resulted in increased epidermal and dermal firmness and thickness

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doi: 10.1097/HC9.0000000000000129 47