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In these studies, the average age of the enrolled subjects was 6065 years, which corresponds to the mean age of onset of PD, although the incidence of PD increases with age (12% over 65 years old and more than 5% over 80 years old)

otherwise, the challenges posed by an excessively growing aging population will become unmanageable (Gonzalez-Freire et al., 2020)

The key is consistency: creatine builds up in your system over 46 weeks, so results appear gradually as muscle creatine stores accumulate

Furthermore, given the limited sample size and the heterogeneity of the antipsychotic drugs administered, results should be interpreted with caution

Reasonable confounding factors did not significantly affect the validity of the results, leading to a high quality of evidence rating for these outcomes (Table 4)

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