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The increased levels of aconitate decarboxylase 1 result in diversion of cis -aconitate away from the TCA cycle via its metabolism to itaconate
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In the pool of placebo-controlled trials in adults, severe gastrointestinal adverse reactions occurred more frequently among patients receiving MOUNJARO (5 mg 1.3%, 10 mg 0.4%, 15 mg 1.2%) than placebo (0.9%)
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