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Moreover, these leukocyte-endothelial cell interactions can also directly contribute to increase BBB permeability by releasing reactive oxygen species, cytokines, and other mediators of barrier disruption [60]

doi: 10.1186/s13075-016-1129-4 287 XuDJiangYYangLHouXWangJGuWet al

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Antioxidants, 12 (9), 1653

This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake

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