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He also explores how GLP-1based therapies affect different fat depots throughout the body, identifies who may be most vulnerable to muscle loss, and outlines practical strategies for preserving muscle and bone health while using these medications

On the other hand, MEDI0382 has been more extensively examined in multiple phase 2 RCTs, on diabetic obese patients, exhibiting significant reductions in blood glucose and body weight, 4850 alone or in combination with other antihyperglycemic agents (NCT02548585, NCT03444584, NCT03645421, NCT03244800, NCT03235050, NCT03745937, NCT03596177, NCT04019561)