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Eur J Intern Med 22(4):355362

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H., Narimani N., Atarod, M

To synthesize the dimeric macrocycles, a 22-mM solution of the respective C-terminal cysteine-modified monomer peptide in DMSO was incubated with 10 mM of the bis-maleimide linker in 50 mM Hepes-HCl (pH 7.5) with 90% (v/v) DMSO

Clinical studies showing significant wrinkle reduction and skin firmness improvements have typically used formulations within this range

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