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Two-way ANOVA was used when comparing WT, Rab4A Q72L and Rab4A Q72L -KO mice between control B6 and lupus-prone B6.TC strains

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Moreover, LIRA significantly suppressed the expression of proinflammatory and profibrotic biomarkers, including NF-B, CD68, IL-1, TGF-1, osteopontin, and nitrotyrosine, in comparison to vehicle-treated rats [66]

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Rise in cAMP and calcium level induces calcineurin-mediated dephosphorylation of CRTC that facilitates its release from 14-3-3 complexes