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A population-based cohort study of Medicare beneficiaries with heart failure with preserved ejection fraction (HFpEF) found that, although spironolactone population-level initiation increased following the TOPCAT trial, there was no corresponding rise in hyperkalemia-related hospitalizations [57]

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In extreme situations, losses to vision can occur within hours of onset, and while this effect can worsen in the following weeks, once the optic nerve's swelling goes down after a month or two, there can be some visual improvement

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