doi: 10.1007/s12020-017-1440-0 [PubMed: 29030774] [CrossRef] 76
The analysis included eight randomized controlled trials with 2,372 participants (all with BMI 27 kg/m) and found that weight regain was proportional to the amount initially lost.48 On average, participants who had taken liraglutide regained 2.2 kg, while those who had taken semaglutide or tirzepatide regained 9.69 kg after stopping the medication.48 Similarly, a 2025 review in Biomolecules showed that patients treated with GLP-1 or dual GLP-1/GIP agonists experience substantial weight loss (ranging from about 6% to over 20%) but also significant weight regain upon drug discontinuation
It is about a fundamental shift in how your body processes energy and how you relate to food
Weight loss and blood sugar improvements may temporarily plateau or fluctuate during the adjustment period
However, this side effect tends to decrease over time
If we dont deal with the problem, then were just amplifying the yo-yo thats been here for many years losing weight, regaining it, says Wyatt, coauthor of Losing the Weight Loss Meds: A 10-Week Playbook for Stopping GLP-1 Medications Without Regaining the Weight