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One common target for potentially improving athletic performance involves increasing blood flow to muscles through vasodilatory processes that are mediated by increases in nitric oxide

Balali-Mood et al., 2021)

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In addition, chronic pain triggers "central sensitization," where your brain amplifies the muscle pain

For patients with cardiovascular or kidney disease, SGLT2 inhibitors or GLP-1 receptor agonists (oral or injectable) may be considered as part of first-line therapy for their cardiorenal benefits