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Within the cytosol of cells, glutathione is kept primarily in the reduced GSH form, largely by reduction of GSSG by the enzyme glutathione reductase, at the expense of NADPH: The mechanism of this reaction is complex, as the enzyme contains a pair of cysteine residues that reversibly form a disulfide bond, plus one FAD molecule (3)

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The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

Notably, while PROTACs can alter the existing pathological phenotype of AD, they cannot reverse the damage that has already occurred, particularly in addressing the genetic mutations associated with FAD (Fig

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