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Fluctuations in ROS levels can influence the function of protein kinases, phosphatases, and various enzymatic proteins, thereby affecting critical processes such as cellular metabolism, gene regulation, and proliferation [25]

HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67

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